August 25, 2016
Abstract of the paper published August 22, 2016 in the journal Nature Methods below.
Shrinkage-mediated imaging of entire organs and organisms using uDISCO
Recent tissue-clearing approaches have become important alternatives to standard histology approaches. However, light scattering in thick tissues and the size restrictions on samples that can be imaged with standard light-sheet microscopy pose limitations for analyzing large samples such as an entire rodent body.
We developed "ultimate DISCO" (uDISCO) clearing to overcome these limitations in volumetric imaging. uDISCO preserves fluorescent proteins over months and renders intact organs and rodent bodies transparent while reducing their size up to 65%.
We used uDISCO to image neuronal connections and vasculature from head to toe over 7 cm and to perform unbiased screening of transplanted stem cells within the entire body of adult mice. uDISCO is compatible with diverse labeling methods and archival human tissue, and it can readily be used in various biomedical applications to study organization of large organ systems throughout entire organisms.
As a reward for reading this far, you get to watch a cool video
showing a trip into a mouse brain.
[via Business Insider]
The Spectacular Nixie Clocks of Dalibor Farny
Dalibor Farny (below)
of the Czech Republic is the majordomo of this movement.
Can he build one for you?
He's standing by to take your call: +420 724 321 571
August 24, 2016
Happy 12th Anniversary To Me
They say the first 12 years are the hardest.
NodPod — Sleep anywhere and put an end to annoying head flop
Res ipsa loquitur.
But in case you're deaf or unable to translate from the Latin, The Verge had this to say:
The NodPod solves a real problem.
When we fall asleep in random places — on airplanes or in a car — our heads nod and we temporarily wake up.
1. This is annoying.
2. It hurts your neck.
It's a big-time sleep bummer.
The NodPod is essentially a head cradle.
It prevents your head from bobbing and lets you sleep more soundly.
Here's the thing with it, though: it looks incredibly nerdy.*
I'm sure people would envy you if you had it on a plane, but I also think you'd definitely be the subject of some teen's discrete snaps.
Whatever, though, right?
Being practical doesn't mean you have to be fashionable.
It's hard to get sleep on a plane, a train, or in any chair, really.
Thank God that the NodPod finally exists.
This thing is basically a hammock for your big fat head, holding it in place so you can sleep.
The ladies in the pictures above and below are either super comfortable because of the NodPod or all drugged up from going to the dentist.
Either way they're loving having their heads supported for a change.
The NodPod looks ideal for car travel
though I'm not too sure about it there since it might break your neck in a car accident.
But you won't care, you'll be sleeping.
Resting in peace.
Go to the light.
Your heavy head is no more.
On the fence?
Why not waste a little more of your employer's time and watch the video?
Me, I'll have to pass: I can just see myself waking up gasping for breath while I strangle myself on the connecting cords during a particularly intense dream.
*Not to worry: I mean, you bought one of these
so it's not as if you care what anyone else thinks.
August 23, 2016
World's Top 10 Most Liveable Cities
[via The Economist]
Wall Stud Finder Gives You X-Ray Vision
Why wait for the next X-Man movie when you can be one?
From The Verge:
The Walabot is the stud finder of the future, connecting to a smartphone to let you see inside your walls.
The $199 price tag aside, it does come with a few features lacking in a run-of-the-mill $15 stud finder from the local hardware store.
Made by Vayyar Imaging, a company specializing in 3D-imaging sensors, the Walabot lets you see plastic and metal pipes, electric wires, and studs at distances up to 4 inches inside a wall.
You can then visualize the actual location of the pipes and wires through a connected Android smartphone running 5.0 Lollipop and above with USB OTG.
Vayyar Imaging also touts the Walabot's ability to sense motion, suggesting that it can be used to find pests in your walls.
Note: incompatible with iPhone.
August 22, 2016
My Wikipedia Page
Ultra-Highly Reflective Bicycle Spoke Clips — "Be seen on your bike at night"
As the days get shorter, bike commuters have to find ways to make themselves more visible when riding in the dark.
Usually cyclists buy lights only for the front and back of their bikes, leaving themselves vulnerable from the side because they aren't easily seen.
Features and Details:
• No batteries required
• Easy to put on and take off
• Super-bright, highly-reflective 3M Scotchlite
• Boring enough no one wants to steal them
• Cheap in case they do
36 for $13.99.
[via Cool Tools]
August 21, 2016
George Orwell's Six Rules of Thumb for Clarity in Writing
1. Never use a metaphor, simile, or other figure of speech which you are used to seeing in print.
2. Never use a long word where a short one will do.
3. If it is possible to cut a word out, always cut it out.
4. Never use the passive where you can use the active.
5. Never use a foreign phrase, a scientific word, or a jargon word if you can think of an everyday English equivalent.
6. Break any of these rules sooner than say anything outright barbarous.
If I taught English at any level, I'd put these at the front of the classroom high enough so that they were always visible to daydreamers like me.
[From his 1946 essay "Politics and the English Language"]
Black Angora Rock
[via PROJECT No. 8]
August 20, 2016
World's First Wheelchair Back Flip — "The learning curve can be rough"
More: "Among the wheelchair sports stars gathering at the Abilities Expo this weekend in Anaheim, California was 17-year-old Las Vegas native Aaron 'Wheelz' Fotheringham, who is credited with performing the world's first wheelchair backflip [top]. Mr. Fotheringham taught himself to ride halfpipes and do tricks alongside skateboarders and BMX riders in his wheelchair. The learning curve can be rough. Attempting his first backflip, he says, 'I would keep going for it and landing on my back, or landing in the foam pit and almost suffocating because I was stuck upside down and couldn't unhook my buckle on my seat.'"
What is it?
Answer here this time tomorrow.
Hint: smaller than a bread box.
A second clue: inanimate.
A third insinuacíon: inedible.
August 19, 2016
"Picnic in Space" starring Marshall McLuhan
YouTube caption: "''Picnic in Space' (1963) is a rare jewel of a film in which McLuhan banters with his long time cohort Harley Parker. The film sees McLuhan expounding on space and its properties while lying in a field somewhere in Canada. Amusing, classic, and a period piece of McLuhan ephemera."
I found it enchanting.
Archelis Wearable Chair
Standing desks are so over.
From TECH TIMES:
Japanese researchers have developed a wearable chair called Archelis that can help surgeons when they are performing long surgeries.
The wearer of Archelis will not get the full comfort of sitting on a chair — which wraps around the wearer's buttocks and legs — but, rather, support allowing the user to sit back wherever and whenever needed.
Fair warning: I hope your Japanese is up to speed.